Short-term stability studies of amorphous cyclodextrin complexes prepared by co-grinding

Balázs Attila Kondoros; Ildikó Csóka; Rita Ambrus

doi:10.33892/aph.2023.93.53-56

Short-term stability studies of amorphous cyclodextrin complexes prepared by co-grinding

Authors

Balázs Attila Kondoros Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary
Ildikó Csóka Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary
Rita Ambrus Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary

DOI:

https://doi.org/10.33892/aph.2023.93.53-56

Keywords:

milling, XRPD, DSC, recrystallization, Terbinafine, Fenofibrate

Abstract

Cyclodextrins (CD) are used for various purposes in the pharmaceutical industry. Conventionally complexes are prepared via solvent methods to encapsulate active pharmaceutical ingredients (API). Co-grinding is an effective alternative way of preparing CD complexes. However, stability studies of these products are not yet fully studied. Our aim was to execute short-term stability studies of complexes with 2 APIs (Terbinafine HCl and Fenofibrate) and a CD derivative. The results of the stability tests showed that different products showed stable amorphous properties under normal conditions and different crystalline stability under accelerated stability tests.

PDF for Kondoros et al. APH 2023;93:53-56

Published

2023-10-15

How to Cite

(1)

Kondoros, B. A.; Csóka, I.; Ambrus, R. Short-Term Stability Studies of Amorphous Cyclodextrin Complexes Prepared by Co-Grinding. Acta Pharm Hung 2023, 93, 53-56.