Stability testing of cyclodextrin-based meloxicam potassium containing nanospheres intended for nasal administration

Patrícia Varga; Csilla Balla-Bartos; Rita Ambrus

doi:10.33892/aph.2023.93.57-62

Stability testing of cyclodextrin-based meloxicam potassium containing nanospheres intended for nasal administration

Authors

Patrícia Varga Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary
Csilla Balla-Bartos Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary
Rita Ambrus Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary

DOI:

https://doi.org/10.33892/aph.2023.93.57-62

Keywords:

stability test, cyclodextrin, meloxicam potassium, nasal drug delivery, nasal powder

Abstract

Nasal delivery of drugs may substitute the parenteral or oral administration. Among the nasal drug delivery systems, powders have favourable properties such as their good adhesion to the mucosa or their improved stability due to their low moisture content. In this work, two cyclodextrin-based meloxicam potassium-containing nasal powder formulations were tested applying the accelerated stability test conditions according to the ICH guideline. Based on the results, the hydroxypropyl- β-cyclodextrin containing sample showed better stability, however, the experienced morphological change is a problem to be solved.

PDF for Varga et al. APH 2023;93:57-62

Published

2023-11-02

How to Cite

(1)

Varga, P.; Balla-Bartos, C.; Ambrus, R. Stability Testing of Cyclodextrin-Based Meloxicam Potassium Containing Nanospheres Intended for Nasal Administration. Acta Pharm Hung 2023, 93, 57-62.