Lanostane Triterpenes with Antimicrobial Activity: A Study of the Pholiol Series from the Hungarian Edible Mushroom Pholiota populnea

Authors

  • Morteza Yazdani HUN-REN – USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary; Institute of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary
  • Annamária Kincses Institute of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary
  • Judit Hohmann HUN-REN – USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary; Institute of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary

DOI:

https://doi.org/10.33892/aph.2024.94.1-6

Keywords:

pholiols, triterpenes, Pholiota populnea, antimicrobial activity

Abstract

Aims: Pholiota populnea is an edible macrofungus, distributed worldwide wherever cottonwood occurs. This study aimed to explore the potential antimicrobial properties of isolated lanostane triterpenes from P. populnea, namely pholiols A-D, E, G, H, J, L, and Q.

Methods: A diverse range of microorganisms, including Gram-negative, and Gram-positive bacterial and fungal strains were employed to assess the antimicrobial activity of these natural triterpenes.

Results: Among the investigated compounds, pholiol C [3β-acetoxy-2α-(3-hydroxy-3-methylglutaroyloxy)-12β,25-dihydroxylanosta-8-en-24-one] exhibited significant activity against Gram-positive bacteria, with minimum inhibitory concentrations (MIC) of 100 µM against Streptococcus agalactiae, and 200 µM against Staphylococcus aureus, S. aureus MRSA, S. epidermidis, Enterococcus faecalis, and Bacillus subtilis. Additionally, pholiols G and E displayed notable inhibitory properties against the S. agalactiae strain, both exhibiting a MIC value of 200 µM.

Conclusion: These findings underscore the potential of the mushroom P. populnea as a noteworthy source of triterpenes possessing antimicrobial activity.

Graphcal abstract

Published

2024-09-09

How to Cite

(1)
Yazdani, M.; Kincses, A.; Hohmann, J. Lanostane Triterpenes With Antimicrobial Activity: A Study of the Pholiol Series from the Hungarian Edible Mushroom Pholiota Populnea. Acta Pharm Hung 2024, 94, 1-6.

Issue

Vol. 94 No. 1 (2024)

Section

Original Research Articles

Copyright (c) 2024 Acta Pharmaceutica Hungarica

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

APH is published as a diamond open-access journal under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Creative Commons License